Many researchers work to inhibit Tyrosinase activity and prevent hyperpigmentation. They’ve found that results can be amplified by utilizing multiple actives that use different modes of action to inhibit melanin production.
Combining the following modes of action can help deliver enhanced results. Further, the use of light-diffusing ingredients such as Titanium Dioxide is an efficient way to quickly balance the appearance of uneven pigmentation while other actives work with the melanin synthesis pathway.
1. Inhibit tyrosinase activity
As described in the previous section, Tyrosinase is a key enzyme that converts the Amino Acid Tyrosine into melanin – so inhibiting its activity can help to reduce melanin production. Hexylresorcinol is a potent active that can bind to Tyrosinase directly, inhibiting its activity. Hexylresorcinol can also stimulate the synthesis of Glutathione – a natural antioxidant present in the skin that helps to decrease Tyrosinase activity. Black Currant, rich in Omega 6 and 3, also helps to decrease the action of Tyrosinase.
2. Block the transfer of melanosome to keratinocytes
Niacinamide (Vitamin B3) has been found to significantly decrease hyperpigmentation by inhibiting the transfer of melanosomes from melanocytes to keratinocytes.
3. Decrease tyrosinase production
Lowering the amount of Tyrosinase means that less enzyme will be available to initiate the melanin production cycle. Peony Flower, rich in Paeonol (a phenolic component), is able to decrease the production of Tyrosinase. Niacinamide (Vitamin B3 ) helps even skin tone by inhibiting melanin transfer Nucleus Nucleus Melanocyte Keratinocyte 7.
4. Melanin breakdown
Because melanin is a protein, it can be degraded by certain enzymes – forming a complex with a less intense colour. Shiitake Mushroom has a biocatalytic action and is able to break down melanin pigment, reducing the intensity of hyperpigmented areas. It is also rich in beta-glucans that provide anti-inflammatory and antioxidant benefits to help combat hyperpigmentation.
5. Protection against pollution
Pollution particles can become lodged in the skin and oxidize the surrounding tissue, leading to free radical damage and uneven pigmentation. Film-forming polymers, together with specific Amino Acid derivatives, can form a protective shield to prevent pollutant adhesion onto the skin, thus reducing pollution-induced dark spots.
6. Neutralize free radicals
Given that the free radicals produced by keratinocytes can overstimulate melanocytes and lead to melanogenesis, powerful antioxidants are one of the keys in combating hyperpigmentation. Ashwagandha – also known as Indian Ginseng – is a powerful antioxidant and has been proven to neutralize free radicals.